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dibenzodiazepine clozapine, clozaril typical maintenance dose 150-225 mg twice daily 300-600 mg day oldest second generation antipsychotic introduced in 1989 most adverse side effect profile of second generation agents agranulocytosis unique to clozapine and fda limits prescribers due to this effect causes anticholinergic effects, sedation, postural hypotension, seizures, weight gain, dyslipidemia severe cns depression in overdose illoperidone fanapt, fanapta, zomaril typical maintenance dose 6-12 mg orally twice daily higher risk of qtc prolongation lurasidone latuda typical maintenance dose 40-160 mg day significant cns depression in overdose olanzapine zyprexa typical maintenance dose 10-20 mg day agitation 10-20 mg oral or im may cause elevated creatinine kinase ck significant cns depression in overdose paliperidone invega sustained release formulation of the active metabolite of risperidone typical maintenance dose 3-6 mg day maximum 12 mg day also available as long acting formulation initial dose 234 mg im next dose 156 mg im at 1 week after initial dose next dose 39 to 234 mg im monthly, at 1 month after second dose quetiapine seroquel typical maintenance dose 250-600 mg day may cause tachycardia severe cns depression in overdose risperidone risperdal typical maintenance dose 3-6 mg day agitation 4 mg orally daily may cause dystonia ziprasidone geodon typical maintenance dose 40-80 mg day agitation 10 mg im every 2 hours or 20 mg im every 4 hours higher risk of qtc prolongation significant cns depression in overdose aripiprazole abilify typical maintenance dose 10-30 mg day significant cns depression in overdose.
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